A boosting skin vaccination with dissolving microneedle patch encapsulating M2e vaccine broadens the protective efficacy of conventional influenza vaccines
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چکیده
منابع مشابه
Dissolving Microneedle Patch for Rabies DNA Vaccination in Dogs
J. Arya , Y-W. Chen , K. Dewitt , Y-W. Chiang , M. R. Prausnitz 1 1 Georgia Institute of Technology, 2 Merial Ltd. Purpose To stabilize rabies DNA vaccine in a dissolving microneedle patch and evaluate immunogenicity and dose sparing in dogs. Rabies is mainly a disease of animals, whereas humans get rabies primarily when they are bitten by dogs. Vaccinating domestic dogs and other animals has r...
متن کاملLong-term protective immunity from an influenza virus-like particle vaccine administered with a microneedle patch.
Skin vaccination with influenza virus-like particles (VLPs) using microneedles has been shown to induce protection similar to or better than that induced by intramuscular immunization. In this study, we examined the long-term protective efficacy of influenza (H1N1 A/PR/8/34) VLPs after skin vaccination using microneedle patches coated with the vaccine. Microneedle vaccination of mice in the ski...
متن کاملDissolving microneedle vaccine delivery systems
It iswell-established that the transdermal route is an attractive alternative for minimally-invasive drug delivery. The potential of the skin as a site for vaccine delivery has been demonstrated over the past decade, with research indicating stronger immune responses and improved duration of immunity compared with conventional intramuscular administration. Benefits of this minimally invasive va...
متن کاملStabilization of Influenza Vaccine Enhances Protection by Microneedle Delivery in the Mouse Skin
BACKGROUND Simple and effective vaccine administration is particularly important for annually recommended influenza vaccination. We hypothesized that vaccine delivery to the skin using a patch containing vaccine-coated microneedles could be an attractive approach to improve influenza vaccination compliance and efficacy. METHODOLOGY/PRINCIPAL FINDINGS Solid microneedle arrays coated with inact...
متن کاملTitle: Opportunities and challenges in delivering influenza vaccine by microneedle patch Running title: Delivering influenza vaccine by microneedle patch
Simple and efficacious delivery methods for influenza vaccines are needed to improve health outcomes and to manage possible pandemics in the United States and globally. One approach to meeting these needs is the microneedle patch (MNP), a small array of micron-scale needles that is applied to the skin like a bandage. Because MNPs do not require a conventional needle and syringe, training requir...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2017
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2017.06.017